{"id":754,"date":"2018-09-12T14:37:53","date_gmt":"2018-09-12T04:37:53","guid":{"rendered":"https:\/\/lungfoundation.com.au\/?page_id=754"},"modified":"2024-06-06T14:46:59","modified_gmt":"2024-06-06T04:46:59","slug":"research-gets-results","status":"publish","type":"page","link":"https:\/\/lungfoundation.com.au\/research\/research-overview\/research-gets-results\/","title":{"rendered":"Research gets results"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":3368,"parent":744,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-754","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research gets results - Lung Foundation Australia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lungfoundation.com.au\/research\/research-overview\/research-gets-results\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research gets results - 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A snapshot of recent and current projects includes:<\/p>\n<ul>\n<li>Developing the National Standards for Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease (COPD) to ensure best practice delivery of this exercise and education program.<\/li>\n<li>Immune regulation of Idiopathic Pulmonary Fibrosis (IPF) to support early diagnosis of the disease and the identification of new targeted therapies.<\/li>\n<li>Deep profiling of lung cancer, metastasis and the immune system to identify new therapeutic targets and support early diagnosis that will enable more people to have curative surgery.<\/li>\n<li>Molecular profiling of tumours to identify specific characteristics associated with lung cancer.<\/li>\n<li>The impact of childhood respiratory infection, bronchitis and asthma in the development of reduced lung function \/ COPD in middle age.<\/li>\n<li>Benefits of home based pulmonary rehabilitation in COPD.<\/li>\n<li>Anxiety and depression in IPF, and the impact on long term outcomes.<\/li>\n<li>Facilitation of clinical trials that contribute to new advances in the diagnosis, treatment and management of lung cancer.<\/li>\n<\/ul>\n","link":""},{"acf_fc_layout":"cta_horizontal","heading":"Why should I support research?","copy":"When you make a donation or bequest to lung disease research, you are supporting work towards an increased understanding of lung disease, what causes it, how it can be prevented and how it should be treated.","link":{"title":"Donate","url":"https:\/\/lungfoundation.com.au\/donate\/","target":""},"link_icon":"none","background":{"background_type":"Colour","image":false,"colour":"#ffffff","overlay":"None","repeat":false}},{"acf_fc_layout":"featured_posts_static","heading":"","view_more_link":null,"posts":[{"ID":1547,"post_author":"3","post_date":"2018-09-18 15:11:17","post_date_gmt":"2018-09-18 05:11:17","post_content":"<h4>What are some of the key findings, progress and discoveries you have made, or hope to make, with your research to date?<\/h4>\nI hope to make discoveries that will be developed into more effective therapies for people with Chronic Obstructive Pulmonary Disease (COPD). Our research team led, by Professor Phil Hansbro, has developed a unique experimental model of COPD that is highly representative of human disease. I have used this model to collect preliminary evidence that shows that the levels of a recently discovered type of molecule, known as microRNAs, changes as the disease progresses. So far, I have shown that one of these microRNAs plays important roles in the development of experimental COPD and that it is also changed in humans with this disease.\n<h4>What do you hope to achieve with this research project?<\/h4>\nThe overarching goal of this research project is to increase the understanding of the mechanisms that drive the development of COPD. I will target specific microRNAs that are changed in experimental COPD to examine their roles and potential for therapeutic targeting, and then confirm my observations in human patients.\n<h4>How important was the funding from Lung Foundation Australia to your work?<\/h4>\nThe funding from Lung Foundation Australia will provide me with an invaluable opportunity to pursue my research, which aims to identify the mechanisms that drive the development of COPD and new therapeutic targets. This research project would not be possible without funding from Lung Foundation Australia.\n<h4>Do you have a message for Lung Foundation Australia\u2019s supporters?<\/h4>\nLung Foundation Australia is an incredible organisation that actively supports the next generation of scientists to pursue cutting edge research in a range of chronic lung diseases. This kind of support enables Australia to remain at the forefront of lung research and fosters early career lung research scientists. This fellowship is essential for me to continue my research, which has strong translational potential, and to further develop my career. I would like to personally thank all of the supporters of Lung Foundation Australia for this opportunity.","post_title":"Dr Richard Kim","post_excerpt":"","post_status":"publish","comment_status":"open","ping_status":"closed","post_password":"","post_name":"richard-kim","to_ping":"","pinged":"","post_modified":"2020-10-07 20:31:30","post_modified_gmt":"2020-10-07 10:31:30","post_content_filtered":"","post_parent":0,"guid":"https:\/\/lungfoundation.com.au\/?post_type=researcher&#038;p=1547","menu_order":0,"post_type":"researcher","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1559,"post_author":"3","post_date":"2018-09-18 15:43:36","post_date_gmt":"2018-09-18 05:43:36","post_content":"<h4 style=\"text-align: center\">For Dr Clare Weeden, research means everything. It means hope for the next generation of lung cancer patients.&nbsp;<\/h4>\n<p><strong>What are some of the key findings, progress and discoveries you have made with your research to date \u2013 and how will this make a difference to patients with this disease?<\/strong><\/p>\n<p>Our research has previously focused on lung squamous cell carcinoma \u2013 the second most common subtype of lung cancer. Lung squamous cell carcinoma is often diagnosed too late, when the cancer is inoperable. Therefore, the ability to detect this cancer early would help more patients have life-saving surgery. We identified the cells that are likely to give rise to lung squamous cell carcinoma, known as basal stem cells, that are present in healthy airways. We uncovered evidence that these cells are the \u201cseed\u201d from which lung squamous carcinomas grow. The hope going forward is our discovery will allow for the earlier detection of aberrant basal stem cells and enable more patients to have curative surgery.<\/p>\n<p>We have also investigated how to better treat lung squamous cell carcinomas with \u201ctargeted\u201d, personalised medicine. We identified a \u2018biomarker\u2019 that would better categorise the patients who would respond to promising new anti-cancer drugs called FGFR (Fibroblast Growth Factor Receptor) inhibitors. We hope this work will allow for the right participants to be recruited into clinical trials to evaluate the efficacy of this new targeted therapy. Our recent work has also found that two BH3-mimetics and one FGFR inhibitor were able to block cancer cell survival so successfully in pre-clinical models that tumours not only stopped growing, they began to shrink away. The next step in our research is working to develop new drugs that can block these molecules safely and effectively in patients.<\/p>\n<p><strong>What do you hope to achieve with this research project?<\/strong><\/p>\n<p>My research project investigates lung cancer metastasis. Over 70% of lung cancer patients present with cancers that have spread from the \u2018primary\u2019 lung cancer to other parts of the body and this renders their cancer inoperable. Such patients rely on chemotherapy, radiotherapy and more recently immunotherapy to slow the growth of their tumours, yet this treatment is rarely curative. There is a desperate need to design new treatments that target metastases, which requires an understanding of the unique features of these cancer cells and their microenvironment. I am profiling the cancer cells and immune cells from \u2018primary\u2019 and metastatic sites within lung cancer patients to identify novel targets for treatment. Our work relies on the generosity of lung cancer patients, and collaboration between clinicians and basic scientists. We hope this project will go on to improve treatment options for the majority of lung cancer patients who present with inoperable tumours.<\/p>\n<p>Dr. Clare Weeden hopes that in the future, lung cancer will become a manageable disease.&nbsp;<\/p>\n<p><strong>How important was the funding from Lung Foundation Australia to your work?<\/strong><\/p>\n<p>The Deep Manchanda Early Career Fellowship is crucial in supporting me to continue my work in lung cancer and lung diseases. This funding allows me to ask challenging research questions and perform state-of-the-art experiments to answer them. Funding opportunities for young researchers can be scarce. Having dedicated funding support for lung diseases attracts more researchers to tackle these projects, and with more research comes more discoveries that have the potential to improve the health of patients living with lung diseases.<\/p>\n<p><strong>Do you have a message for Lung Foundation Australia\u2019s supporters?<\/strong><\/p>\n<p>Despite being the leading cause of cancer death, lung cancer research currently receives only 5% of cancer research funding in Australia. Your support evens this gap, and funds research that has real-world impact on the lives of patients. Thank you for supporting our research into lung cancer and lung disease, it truly makes our work possible.<\/p>\n\n<!-- wp:heading {\"textAlign\":\"center\",\"style\":{\"color\":{\"text\":\"#4f9837\"}}} -->\n<h2 class=\"has-text-align-center has-text-color\" id=\"block-5abf52d1-6a14-4e0e-a4f0-3e5577014a33\" style=\"color:#4f9837\">Research saves lives and gives hope for a cure.<br><strong>Give hope. Give to research today<\/strong>.<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:buttons {\"align\":\"center\"} -->\n<div class=\"wp-block-buttons aligncenter\"><!-- wp:button {\"style\":{\"color\":{\"background\":\"#4f9837\"}}} -->\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-background\" href=\"https:\/\/lungfoundation.com.au\/donate\/\" style=\"background-color:#4f9837\" target=\"_blank\" rel=\"noreferrer noopener\">Donate today<\/a><\/div>\n<!-- \/wp:button --><\/div>\n<!-- \/wp:buttons -->\n\n<!-- wp:separator -->\n<hr class=\"wp-block-separator\" \/>\n<!-- \/wp:separator -->\n\n<!-- wp:media-text {\"mediaId\":11728,\"mediaLink\":\"https:\\\/\\\/lungfoundation.com.au\\\/stories\\\/lachlans-story\\\/bev-and-lachlan-2\\\/\",\"mediaType\":\"image\"} -->\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img src=\"https:\/\/lungfoundation.com.au\/wp-content\/uploads\/2020\/11\/Bev-and-Lachlan-1-1024x704.jpg\" alt=\"\" class=\"wp-image-11728 size-full\" \/><\/figure><div class=\"wp-block-media-text__content\"><!-- wp:heading {\"level\":4} -->\n<h4>30 Reasons for Research <\/h4>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>The work of Dr Clare Weeden is giving hope to\u00a0people like\u00a0Lachlan, who was diagnosed with lung cancer at the age of just 20. Eight years after his devastating diagnosis, Lachlan has experienced first-hand how life-changing treatment is allowing him to live a \u201cnormal\u201d life.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:buttons -->\n<div class=\"wp-block-buttons\"><!-- wp:button -->\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"https:\/\/lungfoundation.com.au\/stories\/lachlans-story\/\">Read Lachlan's story<\/a><\/div>\n<!-- \/wp:button --><\/div>\n<!-- \/wp:buttons --><\/div><\/div>\n<!-- \/wp:media-text -->\n\n<!-- wp:paragraph -->\n<p><\/p>\n<!-- \/wp:paragraph -->","post_title":"Dr Clare Weeden","post_excerpt":"","post_status":"publish","comment_status":"open","ping_status":"closed","post_password":"","post_name":"dr-clare-weeden","to_ping":"","pinged":"","post_modified":"2021-03-05 15:30:48","post_modified_gmt":"2021-03-05 05:30:48","post_content_filtered":"","post_parent":0,"guid":"https:\/\/lungfoundation.com.au\/?post_type=researcher&#038;p=1559","menu_order":0,"post_type":"researcher","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1555,"post_author":"3","post_date":"2018-09-18 15:31:50","post_date_gmt":"2018-09-18 05:31:50","post_content":"<p><b><span data-contrast=\"none\">For\u202f<\/span><\/b><b><span data-contrast=\"none\">Tylah<\/span><\/b><b><span data-contrast=\"none\">&nbsp;Miles, research means<\/span><\/b><b><span data-contrast=\"none\">&nbsp;hope&nbsp;<\/span><\/b><b><span data-contrast=\"none\">that&nbsp;<\/span><\/b><b><span data-contrast=\"none\">patients<\/span><\/b><b><span data-contrast=\"none\">&nbsp;<\/span><\/b><b><span data-contrast=\"none\">can live a long and happy life with their loved ones.<\/span><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559738&quot;:200,&quot;335559739&quot;:200,&quot;335559740&quot;:276}\">&nbsp;<\/span><\/p>\n<p><b><span data-contrast=\"auto\">What are some of the key findings, progress and discoveries you have made with your research to date \u2013 and how will this make a difference to patients with this disease?\u202f<\/span><\/b><span data-contrast=\"auto\">\u202f<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:360}\">&nbsp;<\/span><\/p>\n<p><span data-contrast=\"auto\">We have discovered a specific immune cell signature that identifies that a sub-group of patients who were initially diagnosed with Idiopathic Pulmonary Fibrosis (IPF), also present with autoimmune-like features. Although further validation is needed, this signature may be useful in identifying this group of patients early. It is possible that these individuals with altered immune responses may be more likely to respond to treatment with immunotherapy.<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:360}\">&nbsp;<\/span><\/p>\n<p><b><span data-contrast=\"none\">For&nbsp;<\/span><\/b><b><span data-contrast=\"none\">Tylah<\/span><\/b><b><span data-contrast=\"none\">&nbsp;Miles, research means new discoveries and new treatments.<\/span><\/b><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">&nbsp;<\/span><\/p>\n<p><b><span data-contrast=\"auto\">What do you hope to achieve with this research project?<\/span><\/b><i><span data-contrast=\"auto\">\u202f<\/span><\/i><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:360}\">&nbsp;<\/span><\/p>\n<p><span data-contrast=\"auto\">Our research investigates the cell-mediated responses driving lung fibrosis. In our laboratory we combine the analysis of pre-clinical models of disease with the detailed analysis of patient samples. Specifically, we are investigating the functional role of immune cells in the development and progression of lung fibrosis. We hope that in time, identifying how these cells contribute to IPF will lead to the discovery of potential novel therapeutic targets.<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:360}\">&nbsp;<\/span><\/p>\n<p><b><span data-contrast=\"none\">For Tylah Miles, research means improving the quality of life for people with lung diseases.<\/span><\/b><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">&nbsp;<\/span><\/p>\n<p><b><span data-contrast=\"auto\">How important was the funding from Lung Foundation Australia to your work?<\/span><\/b><i><span data-contrast=\"auto\">\u202f<\/span><\/i><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:360}\">&nbsp;<\/span><\/p>\n<p><span data-contrast=\"auto\">This research project forms the basis of my PhD studies, which are jointly funded by a Research Training Program Scholarship from the University of Western Australia and the Lung Foundation Australia Bill van Nierop PhD Scholarship in IPF.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:360}\">&nbsp;<\/span><\/p>\n<p><b><span data-contrast=\"none\">F<\/span><\/b><b><span data-contrast=\"none\">unding from Lung Foundation Australia<\/span><\/b><b><span data-contrast=\"none\">&nbsp;allowed&nbsp;<\/span><\/b><b><span data-contrast=\"none\">me&nbsp;<\/span><\/b><b><span data-contrast=\"none\">to work<\/span><\/b><b><span data-contrast=\"none\">&nbsp;full-<\/span><\/b><b><span data-contrast=\"none\">time&nbsp;<\/span><\/b><b><span data-contrast=\"none\">focusing on the role of immune cells in lung fibrosis.<\/span><\/b><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">&nbsp;<\/span><\/p>\n<p><b><span data-contrast=\"auto\">Do you have a message for Lung Foundation Australia\u2019s supporters?<\/span><\/b><i><span data-contrast=\"auto\">\u202f<\/span><\/i><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:360}\">&nbsp;<\/span><\/p>\n<p><span data-contrast=\"auto\">Our\u202flaboratory<\/span><span data-contrast=\"auto\">-<\/span><span data-contrast=\"auto\">based\u202fresearch relies heavily on grant funding, your fundraising efforts as well as your participation in our clinical sample collection. We would like to thank you, the Lung Foundation Australia\u2019s supporters, for your ongoing support and encouragement. Together we will reduce the burden of chronic respiratory disorders.<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:360}\">&nbsp;<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}\">&nbsp;<\/span><\/p>\n\n<!-- wp:heading {\"textAlign\":\"center\",\"style\":{\"color\":{\"text\":\"#4f9837\"}}} -->\n<h2 class=\"has-text-align-center has-text-color\" id=\"block-6bac9125-62ef-4ef3-a07f-f009ad31f6f7\" style=\"color:#4f9837\">Research saves lives and gives hope for a cure.<br>Give hope. Give to research today.<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:buttons {\"contentJustification\":\"center\"} -->\n<div class=\"wp-block-buttons is-content-justification-center\"><!-- wp:button {\"style\":{\"color\":{\"background\":\"#4f9837\"}}} -->\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-background\" href=\"https:\/\/lungfoundation.com.au\/donate\/\" style=\"background-color:#4f9837\">Donate today <\/a><\/div>\n<!-- \/wp:button --><\/div>\n<!-- \/wp:buttons -->\n\n<!-- wp:separator -->\n<hr class=\"wp-block-separator\" \/>\n<!-- \/wp:separator -->\n\n<!-- wp:media-text {\"mediaId\":2687,\"mediaLink\":\"https:\\\/\\\/lungfoundation.com.au\\\/stories\\\/bills-story\\\/story-card-bill\\\/\",\"mediaType\":\"image\"} -->\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img src=\"https:\/\/lungfoundation.com.au\/wp-content\/uploads\/2018\/09\/Story-Card-Bill.jpg\" alt=\"\" class=\"wp-image-2687 size-full\" \/><\/figure><div class=\"wp-block-media-text__content\"><!-- wp:heading {\"level\":4} -->\n<h4>30 Reasons for Research<\/h4>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>For Bill, the research of&nbsp;those such as&nbsp;Tylah&nbsp;Miles&nbsp;means hope for a greater understanding of lung disease, better medications to deal with it and a slowing of disease progression.&nbsp;Bill was diagnosed with IPF in&nbsp;2015&nbsp;and&nbsp;has since&nbsp;taken on gruelling physical and mental challenges to raise funds for&nbsp;this much needed&nbsp;research.&nbsp;&nbsp;<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:buttons {\"contentJustification\":\"center\"} -->\n<div class=\"wp-block-buttons is-content-justification-center\"><!-- wp:button -->\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"https:\/\/lungfoundation.com.au\/stories\/bills-story\/\">Read Bill's story<\/a><\/div>\n<!-- \/wp:button --><\/div>\n<!-- \/wp:buttons --><\/div><\/div>\n<!-- \/wp:media-text -->","post_title":"Tylah Miles","post_excerpt":"","post_status":"publish","comment_status":"open","ping_status":"closed","post_password":"","post_name":"tylah-miles","to_ping":"","pinged":"","post_modified":"2021-08-20 15:20:43","post_modified_gmt":"2021-08-20 05:20:43","post_content_filtered":"","post_parent":0,"guid":"https:\/\/lungfoundation.com.au\/?post_type=researcher&#038;p=1555","menu_order":0,"post_type":"researcher","post_mime_type":"","comment_count":"0","filter":"raw"}]}],"subtitle":"","disable_header_overlay":false},"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/lungfoundation.com.au\/wp-json\/wp\/v2\/pages\/754","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lungfoundation.com.au\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lungfoundation.com.au\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lungfoundation.com.au\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/lungfoundation.com.au\/wp-json\/wp\/v2\/comments?post=754"}],"version-history":[{"count":8,"href":"https:\/\/lungfoundation.com.au\/wp-json\/wp\/v2\/pages\/754\/revisions"}],"predecessor-version":[{"id":93335,"href":"https:\/\/lungfoundation.com.au\/wp-json\/wp\/v2\/pages\/754\/revisions\/93335"}],"up":[{"embeddable":true,"href":"https:\/\/lungfoundation.com.au\/wp-json\/wp\/v2\/pages\/744"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lungfoundation.com.au\/wp-json\/wp\/v2\/media\/3368"}],"wp:attachment":[{"href":"https:\/\/lungfoundation.com.au\/wp-json\/wp\/v2\/media?parent=754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}